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IC‐P‐176: LONGITUDINAL ASSESSMENT OF TAU WITH [ 18 F]MK‐6240 IN ALZHEIMER'S DISEASE PATIENTS AND COGNITIVELY NORMAL ADULTS AT 6 AND 12 MONTHS
Author(s) -
Salinas Cristian A.,
Purohit Ajay,
Beaver John,
Martarello Laurent
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4291
Subject(s) - nuclear medicine , grey matter , pathological , medicine , alzheimer's disease , white matter , radiology , disease , magnetic resonance imaging
F-MK-6240 binding was greater in medial temporal cortex in amyloid-positive than amyloid-negative subjects (p 1⁄4 0.011). Conclusions: Lack of correlation in amyloid-negative subjects and high putamen binding suggest that F-THK-5351 binds a non-tau target not bound to F-MK-6240. Even in amyloid-positive patients, FTHK-5351 signal appears to be influenced more by off-target binding than by tau. F-MK-6240, in contrast, appears to be specific for tau pathology.