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IC‐P‐170: SUBTHRESHOLD LEVEL TAU DEPOSITION OCCURS PRIOR TO SUBTHRESHOLD AMYLOID DEPOSITION IN COGNITIVELY NORMAL ELDERLY INDIVIDUALS
Author(s) -
Mathotaarachchi Sulantha,
Pascoal Tharick A.,
Benedet Andrea Lessa,
Chamoun Mira,
Kang Min Su,
Therriault Joseph,
Savard Melissa,
Lussier Firoza Zubeida,
Tissot Cecile,
Thomas Emilie,
Fonov Vladimir S.,
Gauthier Serge,
Rosa-Neto Pedro
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4285
Subject(s) - amyloid (mycology) , dementia , psychology , alzheimer's disease , cerebellum , tau pathology , pathology , neuroscience , chemistry , medicine , disease
hippocampal-sparing AD, an atypical neuropathological subtype more frequently seen in males and in younger patients. The other amyloid-positive patient lacking medial temporal F-MK-6240 binding was older (78 years) and had low binding throughout the brain, despite small hippocampal volume (0.50% total intracranial volume, Fig 1C). This case may represent an amyloid pathophysiological process with a concomitant non-tau copathology (A+TN+). Out of 10 amyloid-negative patients, only one had evident F-MK-6240 binding in medial temporal cortex in range of amyloid-positive patients (SUVR 1⁄4 3.14, Fig 1D). This case may represent primary age related tauopathy (PART). Conclusions: F-MK-6240 appears to identify tau pathology in preclinical AD and PART, and to distinguish hippocampal-sparing AD and A+T-N+ from typical AD.