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IC‐P‐169: PATTERNS OF TAU PATHOLOGY IDENTIFIED WITH 18 F‐MK‐6240 PET IMAGING
Author(s) -
Kreisl William Charles,
Johnson Aubrey S.,
Tomljanovic Zeljko,
Klein Julia,
Polly Krista,
Razlighi Qolamreza,
Brickman Adam M.,
Stern Yaakov
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4284
Subject(s) - pathology , standardized uptake value , radioligand , hippocampal formation , neocortex , temporal cortex , amyloid (mycology) , cerebellar cortex , medicine , neuroscience , cerebellum , psychology , positron emission tomography , receptor
target regions and 1 Tissue Compartment Model (1TCM) for different reference regions. The nondisplacable (ND) binding compartments from 2TCM in the targets were compared VT in the reference regions. To validate the reference tissue and its accuracy, 2TCM VT in the targets were associated with Logan reference region method (DVR). Last, the variance of the reference regional fits was examined based on the mean square error. The longitudinal changes in the standard uptake value (SUV) in the reference regions were assessed based on paired-t test with FDR correction. Results: 8 potential reference regions investigated cerebellar grey (CerebGM), cerebellar vermis, pons, striatum, white matter (WM), eroded CerebGM, inferior CerebGM, and Pons & Inferior CerebGM. The striatum, WM, and inferior CerebGM showed significantly different level of ND binding compared to the target ND binding. Furthermore CerebGM, cerebellar vermis, pons, inferior CerebGM, and pons&inferior CerebGM showed significant correlation between VT and DVR in the targets. Moreover, only Pons, Inferior CerebGM, and Pon&inferior CerebGM showed no changes in the SUVafter 1-year follow-up. However, Pons demonstrated the highest variance. Conclusions: Pons fit the appropriate reference region profile. However, it has the highest variability. WM has the lowest variability but does not fit the reference region profile. Our study suggests to explore a composite reference region such as pons&inferior CerebGM for the quantification of [F] MK6240. IC-P-169 PATTERNS OF TAU PATHOLOGY 18 IDENTIFIED WITH F-MK-6240 PET IMAGING