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IC‐P‐157: MAPPING CORTICAL COMPLEXITY OF THERAPEUTIC TARGET IN COGNITIVELY NORMAL ADULTS: TAKING LEFT DORSOLATERAL PREFRONTAL CORTEX AS AN EXAMPLE
Author(s) -
Lu Hanna,
Man Chan Sandra Sau,
Lam Linda C.W.,
Ning Yuping
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4272
Subject(s) - dorsolateral prefrontal cortex , gyrification , prefrontal cortex , stimulation , neuroscience , psychology , cortex (anatomy) , cerebral cortex , medicine , cognition
subjective memory complaints (SMC; n1⁄411) orMCI (n1⁄49), underwent a randomized crossover diet study, with 6-week diet periods separated by a 6-week wash out period. The MMKD and AHAD were isocaloric, starting diet was randomized, and APOE genotype was determined. Subjects underwent 3TMRI prior to their first diet, upon completion of the first diet, and upon completion of their second diet. Blood lipids, insulin, glucose and weight were obtained at the start and finish of each diet. Changes in white matter microstructure were assessed with repeated measures analysis of covariance using general linear modeling, with the dependent variable Fractional Anisotropy (FA) (pre and post diet); age, APOE-E4 status, cognitive status, and diet order were covariates and group (SMC, MCI) was the independent variable. Six white matter tracts vulnerable to decline during AD were identified; mean tract FA values were averaged to create a single microstructural integrity measure. Results: Both diets replicated peripheral metabolic changes seen in previous studies. MMKD was associated with an FA increase for both SMC and MCI (p<.05) that was positively correlated with age. AHAD was associated with reduced FA in the SMC group (p1⁄4.055). Both diets showed significantly greater FA increases in E4 non-carriers (n1⁄413) than carriers (n1⁄46) regardless of diagnosis (both diets p<.05). Conclusions: Study diets affected white matter differentially; while the MMKD increased white matter integrity, the AHAD may only be beneficial for those with MCI. However, the presence of the E4 allele attenuated beneficial effects of both diets. This study shows altering diet can affect white matter microstructure measured by FA in areas vulnerable to AD pathology.