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IC‐P‐149: DECREASED CORTICAL NEURITE DENSITY AND ORIENTATION DISPERSION IN ALZHEIMER'S DISEASE DEMENTIA
Author(s) -
Vogt Nicholas M.,
Adluru Nagesh,
Hunt Jack F.V.,
Oh Jennifer M.,
Asthana Sanjay,
Johnson Sterling C.,
Alexander Andrew L.,
Yu John-Paul,
Bendlin Barbara B.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4263
Subject(s) - dementia , diffusion mri , neuroimaging , atrophy , population , neurite , voxel , psen1 , neuroscience , alzheimer's disease , magnetic resonance imaging , psychology , medicine , artificial intelligence , pattern recognition (psychology) , computer science , biology , pathology , disease , amyloid precursor protein , radiology , biochemistry , environmental health , in vitro
well the clinical groups and tracked the clinical and cognitive progression (Fig 4-bottom). Conclusions: Cortical MD is more sensitive than CTh to detect neurodegenerative changes in AD. We propose a cortical MD AD signature that could be used in clinical trials. IC-P-149 DECREASED CORTICAL NEURITE DENSITYAND ORIENTATION DISPERSION IN ALZHEIMER’S DISEASE DEMENTIA Nicholas M. Vogt, Nagesh Adluru, Jack F. V. Hunt, Jennifer M. Oh, Sanjay Asthana, Sterling C. Johnson, Andrew L. Alexander, John-Paul Yu, Barbara B. Bendlin, Wisconsin Alzheimer’s Disease Research Center, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA; Alzheimer’s Disease Research Center, Madison, WI, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin-Madison, Madison, WI, USA; VA Geriatric Research, Education and Clinical Center (GRECC), William S. Middleton Memorial Veterans Hospital, Madison, WI, USA; University Of Wisconsin School of Medicine and Public Health, Madison, WI, USA. Contact e-mail: nvogt@wisc.edu