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IC‐P‐144: BLAZER: A VERSATILE AND EFFICIENT WORKFLOW FOR ANALYZING PET/MR NEUROIMAGING DATA IN ALZHEIMER'S DISEASE
Author(s) -
Raman Fabio,
Grandhi Sameera,
Murchison Charles F.,
Kennedy Richard E.,
Landau Susan M.,
Roberson Erik D.,
McConathy Jon
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4258
Subject(s) - workflow , neuroimaging , alzheimer's disease neuroimaging initiative , segmentation , posterior cingulate , standardized uptake value , magnetic resonance imaging , artificial intelligence , computer science , nuclear medicine , positron emission tomography , cognitive impairment , medicine , cognition , psychology , disease , neuroscience , radiology , pathology , database
Results: In all extrahippocampal areas and hippocampal subfields, amnestic patients had significantly smaller volumes than controls (all z < -2.6, p<0.02). Non-amnestic patients had greater volumes than amnestic patients in BA 35 (z1⁄4-3.0, p<0.01), entorhinal cortex (z1⁄4-3.4, p<0.01), parahippocampal cortex (z1⁄4-3.0, p<0.01), subiculum (z1⁄4-2.0, p<0.05), CA1 (z1⁄4-2.2, p<0.04), and DG (z1⁄4-4.0, p<0.001). Non-amnestic patients exhibited atrophy relative to controls in BA 35 (z1⁄4-2.3, p<0.04), CA1 (z1⁄4-2.5, p<0.03), and DG (z1⁄4-2.3, p<0.04).Conclusions: Non-amnestic patients demonstrated relative sparing both in the hippocampus and surrounding medial temporal areas. Differences in regional atrophy patterns may indicate that medial temporal sparing in non-amnestic AD is regionally specific.
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