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IC‐P‐141: DEVELOPMENT OF A NOVEL 18 F‐LABELED PET TRACER FOR IMAGING ASTROGLIOSIS
Author(s) -
Okamura Nobuyuki,
Harada Ryuichi,
Michinori Ezura,
Arai Hiroyuki,
Yanai Kazuhiko,
Furumoto Shozo,
Kudo Yukitsuka
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4255
Subject(s) - astrogliosis , biodistribution , monoamine oxidase b , chemistry , pharmacology , in vitro , human brain , binding potential , monoamine oxidase a , monoamine oxidase , toxicity , neurodegeneration , receptor , biochemistry , pathology , central nervous system , medicine , biology , neuroscience , enzyme , disease , organic chemistry
correlations (r>0.30) were noted in 5 regions (Fig. 1): the cuneus (r1⁄40.50), rolandic operculum (r1⁄40.42), triangular part of the inferior frontal gyrus (r1⁄40.37), anterior cingulate gyrus (r1⁄40.33), and rectal gyrus (r1⁄40.30). When averaged for these 5 regions, the correlation was moderate (r1⁄40.56), and receiver operator characteristic analysis performed to predict Ab positivity revealed that the sensitivity was 0.67, the specificity was 0.81, and the area under the curve was 0.76 (Fig. 2). Conclusions: The increased susceptibility of QSM was moderately correlated with amyloid PET according to both intra-patient and inter-patient results. QSM can be used for predicting Ab positivity with moderate diagnostic ability.