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IC‐P‐135: DISTRIBUTION OF AMYLOID DEPOSITS ACROSS THE RETINA IN ASSOCIATION WITH ALZHEIMER'S DISEASE AS A FUNCTION OF DISEASE SEVERITY
Author(s) -
Campbell Melanie CW.,
Ren Ji,
Mason Erik,
Redekop Rachel,
Kitor Monika,
Emptage Laura,
Hirsch-Reinshagen Veronica,
Robin Hsiung Ging-Yuek,
Mackenzie Ian R.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4249
Subject(s) - retina , retinal , pathology , optic nerve , amyloid (mycology) , ophthalmology , anatomy , biology , chemistry , medicine , neuroscience
(Preclinical Alzheimer’s Cognitive Composite and ADAS11Cog). Results: Change rates were significantly higher for T+ preclinical AD than controls, but not for Tones (Table 2, Figure 2). Although BA35, the earliest region of tangle pathology, has the greatest change rate, its effect in preclinical stage is inferior to hippocampus probably because of greater variability in measurement. However, it becomes the best region in prodromal disease in which perhaps the degree of atrophy overcomes its inherent noise. None of the longitudinal cognitive measures reach Bonferroni-corrected significance in preclinical or prodromal AD. Conclusions: Our novel longitudinal measurements of the MTL subregions are sensitive to disease progression in preclinical AD to a greater extent than longitudinal cognitive measures. As such, they may serve as efficient outcome measures in clinical trials. Moreover, accelerated atrophy in preclinical AD seems to occur only in the presence of concomitant tau pathology.