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IC‐P‐127: VARIABILITY IN MRI AND PET MEASUREMENTS INTRODUCED BY CHANGE IN MRI VENDOR
Author(s) -
Schwarz Christopher G.,
Wiste Heather J.,
Gunter Jeffrey L.,
Senjem Matthew L.,
Lowe Val J.,
Petersen Ronald C.,
Knopman David S.,
Jack Clifford R.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4241
Subject(s) - intraclass correlation , nuclear medicine , voxel , magnetic resonance imaging , medicine , partial volume , diffusion mri , reproducibility , radiology , mathematics , statistics
SCD-clinic; by contrast, informant-reported SCD was higher in SCD-clinic than in SCD-community (and higher than controls in both SCD groups). The level of anxiety was higher in both SCD groups than controls while depression was higher in SCD-clinic only (compared to SCD-community or controls). SCD-clinic also showed greater atrophy rate (Fig.1) and cognitive decline at follow-up. Higher self-reported SCD correlated to lower glucose metabolism and grey matter volume in both SCD groups, and to higher amyloid deposition in the SCD-clinic (Fig.1). Conclusions: Our findings suggest that SCD-clinic are more at-risk for clinical decline to dementia than SCD-community, and that SCD-community represents an intermediate stage in a continuum leading to SCD-clinic. They also highlight the relevance of psychoaffective factors as anxiety and depression may increase the risks for cognitive decline, and/or might be early symptoms of AD. Further studies are needed to explore the potential causal relationships between SCD and psychoaffective symptoms along AD stages.