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IC‐P‐109: LOWER ARTERIAL BLOOD FLOW AND HIGHER PULSATILITY INDEX ARE ASSOCIATED WITH NEURONAL INJURY
Author(s) -
Hunt Jack F.V.,
Vogt Nicholas M.,
Cary Paul,
Dean Douglas C.,
Jonaitis Erin,
Cody Karly Alex,
Rivera Leonardo A.,
Carlsson Cynthia,
Okonkwo Ozioma C.,
Asthana Sanjay,
Johnson Sterling C.,
Alexander Andrew L.,
Wieben Oliver,
Bendlin Barbara B.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4223
Subject(s) - white matter , fractional anisotropy , diffusion mri , cerebral blood flow , cardiology , medicine , blood flow , magnetic resonance imaging , nuclear medicine , radiology
SPARE-AD scores (Figure1,2). Importantly, this association was modulated by age: among mid-age individuals (40-65 y.o.), higher WMH volume had a stronger association with accelerated aging (i.e. older brain age than actual age) as compared to individuals at older ages (greater than 80 years) (Figure1). WMH were also associated with SPARE-AD after age 65 (Figure2). Finally, more total WMH volume after age 55 was associated with higher proba-