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IC‐P‐106: PERFORMANCE AND BRAIN ACTIVATION IN A DUAL TASK MIMICKING DISTRACTED WALKING
Author(s) -
Kirby Krystal,
Pillai Sreekrishna R.,
Brouillette Robert,
Keller Jeffrey N.,
De Vito Alyssa,
Bernstein John,
Van Gemmert Arend,
Carmichael Owen T.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4220
Subject(s) - cadence , finger tapping , functional magnetic resonance imaging , audiology , middle frontal gyrus , posterior parietal cortex , rhythm , psychology , supplementary motor area , neuroscience , physical medicine and rehabilitation , medicine
vertebral artery hypoplasia (VAH) demonstrate lower global cerebral blood flow, but it is unknown whether adults with VAH also have lower cerebrovascular reactivity. Thus, the purpose of this study was to compare cerebral hemodynamics and reactivity in adults with VAH compared to adults with normal anatomy (controls). Because several factors are known to influence cerebral hemodynamics, we will also compare adults with VAH to ageand sex-matched controls. Methods: A total of 39 cognitively-normal adults (age1⁄443619 yrs), with no underlying cardiovascular or neurological diseases, participated in this study. Cerebral blood flow and cerebral pulsatility were determined using 4D flow MRI during normoxia and hypercapnia. Cerebrovascular reactivity to hypercapnia was calculated from the linear relationship between the change in blood flow and the change in CO2andwere compared using an unpaired one-tailed student’s t-test. Blood flow was determined in the basilar (BA), internal carotid (ICA), and middle cerebral (MCA) arteries. Results: VAH was identified in 10 of the 39 participants. Global cerebrovascular reactivity, BA reactivity and ipsilateral ICA reactivity were reduced in VAH compared with controls (P<0.05 for all). There was a trend for lower ipsilateral MCA reactivity (P1⁄40.10) and contralateral ICA reactivity (P1⁄40.06) in VAH compared with controls. There was no difference in contralateral MCA reactivity (P1⁄40.43) or global cerebral pulsatility (P1⁄40.50). When groups were matched for age and sex (n1⁄410 VAH, n1⁄410 controls), lower cerebrovascular reactivity in VAH persisted for global cerebrovascular reactivity,BA reactivity, and ipsilateral ICA reactivity (P<0.05 for all), with a trend for lower contralateral ICA reactivity (P1⁄40.06) compared with controls. Ipsilateral (P1⁄40.16) and contralateral MCA reactivity (P1⁄40.42), as well as global cerebral pulsatility (P1⁄40.23), were not different between groups. Conclusions: Individuals with VAH demonstrated lower global cerebrovascular reactivity compared to adults with normal anatomy. Results persisted when adults were matched for age and sex. Future studies should evaluate the potential impact of VAH on the risk of Alzheimer’s disease.