Premium
IC‐P‐049: NEURAL ACTIVATION OF THE ANTERIOR CINGULATE CORTEX PREDICTS SUBSEQUENT LONG‐TERM MEMORY IN MILD COGNITIVE IMPAIRMENT DUE TO ALZHEIMER'S DISEASE
Author(s) -
Schmieschek Maximilian H.T.,
Nellessen Nils,
Lubaca Paulo,
Richter Nils,
Fassbender Ronja,
Fink Gereon R.,
Kukolja Juraj,
Onur Oezguer A.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4211
Subject(s) - anterior cingulate cortex , functional magnetic resonance imaging , psychology , neuroscience , superior frontal gyrus , cognition , neural correlates of consciousness , audiology , alzheimer's disease , hippocampus , memory impairment , gyrus , recall , disease , medicine , cognitive psychology
of hue and the lumen hole within them in trichrome images (Figure 1). Objects smaller than 0.0134mm were excluded and resulting segmentations manually inspected. 414 remaining vessels were classified as arteries or veins after review of coregistered SMA slides (Figure 2). Occlusion of each vessel was calculated as the ratio of the volume of collagen to the total volume (collagen + lumen). T-tests were used to determine characteristic differences between vessel types. Linear regressions, accounting for age at death and MRI to death interval, determined relationships between WMH and occlusions in veins and arteries. WMH, segmented from T2-weighted images, was log-transformed and corrected for intracranial volume. Results: 414 total vessels were analyzed of which 60.6% (n1⁄4251) were arteries. Veins were larger (p<.001), less occluded (p<.001) and closer to the ventricular wall (p<.005) than arteries. Veins in the most anterior slice were more occluded than those in posterior slices (p1⁄4.014). The degree of occlusion of veins due to collagenosis was correlated with WMH volume (p1⁄4.007). Arterial occlusion was not related to WMH volume (p1⁄4.799). Conclusions: Collagenosis of veins is an under-recognized mechanism by which vascular insufficiency contributes to development of MRI WMH in an older population.