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IC‐P‐034: OLFACTORY DEFICITS AND FUNCTIONAL CONNECTIVITY DISRUPTIONS IN PATIENTS WITH SUBJECTIVE COGNITIVE DECLINE (SCD)
Author(s) -
Yang Qing X.,
Lu Jiaming,
Karunanayaka Prasanna,
Zhang Xin,
Zhang Bing
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4196
Subject(s) - piriform cortex , entorhinal cortex , neuroscience , olfactory system , resting state fmri , hippocampus , neurocognitive , amygdala , olfaction , psychology , medicine , audiology , cognition
were identified as relevant if corresponding weights correlated (p<0.01) with corresponding regional SUVR measures or if weights exhibited a diagnostic effect (ANOVA, p<0.01). Relevant nodes and connections (>97.5% PET-pattern OR >97.5% FCpattern) were visualized (Fig.2&4). Results: One FC-Florbetapir (Fig2.A-D, Fig.3) and one FC-Flortaucipir IC (Fig.4A-D,Fig.5) met criteria. The FC-patterns correlated 0.76 and PET-patterns correlated 0.48. Both FC-patterns resembled canonical resting-state networks (Fig.2-3F). In the FC-Florbetapir pattern (Fig.2), relevant nodes consisted primarily of within/ between DMN connections. In the FC-Flortaucipir pattern (Fig.4), relevant nodes primarily consisted of within/ between visual-network connections. Conclusions: The correlation between FC-Florbetapir trait weights and cortical amyloid SUVR was stronger than FC-Flortaucipir trait weights andMTL tau SUVR, likely due to the sample having fewer subjects with diffuse tau than diffuse amyloid. The amyloid trait (Fig.3) was heavily represented in the DMN, consistent with previous literature in later stage subjects. The tau trait was heavily represented in the visual cortex (Fig.5), likely driven by subjects exhibiting diffuse deposition given that these subjects drove the trait’s group effect and correlation with MTL tau (Fig4A-B). The proposed method was able to capture covarying processes between PET and FC changes in AD. Results suggest a prominent role of amyloid on functional connectivity in pre-symptomatic subjects.