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IC‐P‐025: GREY MATTER CONNECTIVITY TRAJECTORIES ACROSS THE ALZHEIMER'S DISEASE CONTINUUM AND ASSOCIATIONS WITH COGNITIVE DECLINE
Author(s) -
Dicks Ellen,
Flier Wiesje M.,
Barkhof Frederik,
Scheltens Philip,
Tijms Betty M.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4187
Subject(s) - dementia , disease , grey matter , cognitive decline , cognition , medicine , alzheimer's disease , psychology , oncology , neuroscience , magnetic resonance imaging , white matter , radiology
accounting for local differences in hemodynamic response. Methods: Whole-brain simultaneous multi-slice resting state fMRI data were acquired on 3T GE 750 scanners at the University ofWisconsin-Madison andMedical College ofWisconsin (8 bands, 72 slices, TR 802 ms, voxel size 2 mm isotropic). Participants were enrolled in the NIH-sponsored Alzheimer’s Disease Connectome Project (Table 1). Slice time correction was applied prior to the Human Connectome Project minimal preprocessing pipeline (Glasser et al., 2013). Separate fully connected spectral DCMs (Friston, Kahan, Biswal, & Razi, 2014) were constructed for the Stanford FIND lab’s left and right ECN (Shirer, Ryali, Rykhlevskaia, Menon, & Greicius, 2012) following nuisance regression. Group differences were investigated via parametric empirical Bayes (PEB) models (Friston et al., 2016). Automated search removed non-evident parameters and a threshold of posterior probability of 95% was used. Results: Three/nine parameters in the left ECN differed between controls and individuals with MCI/AD (Table 2). Eight/ seven parameters in the right ECN differed between controls and individuals with MCI/AD (Table 3). All parameters in the left ECN which differed in MCI compared to controls also differed in AD while 6 difference parameters were in common in the right ECN. Conclusions: ECN EC differed between the three groups. Further investigation is needed to determine how these differences may relate to neuropsychological test results and how parameters differ between MCI and AD.