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IC‐P‐017: AMYLOID PET IS MORE THAN JUST POSITIVE OR NEGATIVE: AMYLOID LEVEL IMPACTS RISK OF CLINICAL PROGRESSION IN NORMAL INDIVIDUALS
Author(s) -
Kall Laura M.,
Burnham Samantha C.,
Dore Vincent,
Mulligan Rachel S.,
Bozinovski Svetlana,
Bourgeat Pierrick,
Tyrrell Regan,
Young Kenneth,
Fripp Jurgen,
Masters Colin L.,
Villemagne Victor L.,
Rowe Christopher
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4179
Subject(s) - dementia , medicine , proportional hazards model , amyloid (mycology) , cognition , cognitive decline , pittsburgh compound b , gerontology , oncology , disease , pathology , psychiatry
and sex-matched individuals were included (Tab. 1). Amyloid status was based on qualitative ratings of [18F]florbetaben (Neuraceq) PET scans by two experienced readers. Global cortical amyloid burden was quantified by standard uptake value ratios relative to a cerebellar cortex reference region (SUVRglobal). For each participant, 3D-T1weighed MRI data were acquired. Cholinergic forebrain volumes were extracted based on the procedure described by Kilimann et al. (2014). We specifically tested group differences in Ch4p volume between SCDAß+ and SCDAßand conducted a correlation analysis between Ch4p volume and SUVRglobal. The other BF subnuclei were also examined exploratively. Results: In this cohort, we found no significant volume differences of the Ch4p between SCDAß+ and SCDAßsubgroups (Tab. 2). However, correlation analyses revealed that the Ch4p volume was significantly negatively correlated with the global amyloid SUVR for the SCDAß+ group only (Fig. 1). The difference between the correlation coefficients for SCDAß+ and SCDAßsubgroups was statistically significant. Explorative analyses for the other BF nuclei did not reveal any significant results. Conclusions: Even though SCDAß+ and SCDAßgroups did not differ with regard to the BF volumes, our data indicate that in individuals who already developed significant cortical amyloid depositions, reductions of the Ch4p volume align with amyloid load, thus relating Ch4p to AD pathology, possibly in a threshold-dependent manner.