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IC‐P‐013: VASCULAR RISK FACTORS AND MULTIMODAL NEUROIMAGING BIOMARKERS: PRELIMINARY ANALYSES FROM THE MULTIETHNIC STUDY OF ATHEROSCLEROSIS (MESA)
Author(s) -
Lockhart Samuel N.,
Craft Suzanne,
Sachs Bonnie C.,
Rapp Stephen R.,
Jung Youngkyoo,
Whitlow Christopher T.,
Solingapuram Sai Kiran Kumar,
Hayden Kathleen M.,
Burke Gregory L.,
Hughes Timothy M.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4175
Subject(s) - medicine , neuroimaging , framingham risk score , cardiology , cohort , clinical dementia rating , multivariate statistics , dementia , disease , psychiatry , statistics , mathematics
groups. History of depression or traumatic brain injury were negatively associated with PET positivity in patients with MCI, and history of hypertension or ischemic heart disease were negatively associated with PET-positivity in patients with dementia. Multivariate models, based on the significant factors from all categories, reached an area under the curve (AUROC) of 0.648 in MCI and 0.666 in dementia (table 2). Conclusions: In the IDEAS study, age, Caucasian race, female sex, and family history of AD were positively associated with b-amyloid-PET positivity. Hispanic ethnicity, lower dementia severity and relevant medical co-morbidities were associated with a lower likelihood of PET positivity. Combining all significant factors in a single model achieved only a modest prediction of b-amyloid status.