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IC‐P‐011: DOES ACQUISITION TIME AFFECT THE RESULTS OF 18F‐FLORBETABEN IMAGING?
Author(s) -
Johnson Aubrey S.,
Tomljanovic Zeljko,
Klein Julia,
Santi Susan,
Honig Lawrence S.,
Kreisl William Charles
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4173
Subject(s) - cognitive impairment , nuclear medicine , medicine , psychology , pathology , disease
and the progression sequence was highly consistent with estimated pathology spread in the longitudinal trajectory model (Fig.3a). Anterior temporal regions exhibiting first supra-threshold signal displayed a rather moderate signal increase over time, which was rapidly surpassed by the much higher accumulation rates in fronto-parietal regions previously associated with amyloid accumulation in AD (Fig.3b). Longitudinal increases in regional amyloid-positivity were associated with APOE4 status and clinical diagnosis (all p<0.05). Conclusions: Amyloid progression from associative cortex over primary sensory-motor areas to subcortical structures is supported across all methods reviewed and is consistent with neuropathological findings. The physio-pathological origin of early signal increases in the anterior temporal lobe remains to be investigated in more detail.