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P4‐438: MULTIMORBIDITY DEFINED BY TRAJECTORIES OF CARDIOMETABOLIC MARKERS AND FOLLOWING COGNITIVE DECLINE OVER ONE DECADE: FINDINGS FROM THE WOMEN'S HEALTHY AGEING PROJECT
Author(s) -
Shang Xianwen,
Szoeke Cassandra,
Gorelik Alexandra,
Tabesh Marjan,
Dennerstein Lorraine,
Campbell Stephen,
Henderson Victor W.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4110
Subject(s) - cognitive decline , cognition , medicine , dementia , gerontology , cognitive test , disease , demography , psychiatry , sociology
AD after the age 75, though less prominently (p-value1⁄40.01; OR1⁄40.67). Analysis, using Cox model supported these findings. Conclusions: Vaccination against pneumonia (alone or together with flu shot) could be a promising new candidate for repurposing in AD prevention, potentially acting through improving resilience of the immune system in the elderly. Further testing and validation of these effects in other human data is warranted. The study was supported by NIH grants R56AG059428 and R01AG046860.