Premium
P4‐437: EDUCATION, EARLY LIFE ENVIRONMENT, AND LATER LIFE DEMENTIA‐ RELATED NEUROPATHOLOGY
Author(s) -
Tom Sarah E.,
Piotrowski Hien,
Montine Thomas J.,
Crane Paul K.,
Larson Eric B.B.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4109
Subject(s) - neuropathology , socioeconomic status , psychology , dementia , medicine , gerontology , demography , clinical psychology , pathology , disease , environmental health , population , sociology
AD after the age 75, though less prominently (p-value1⁄40.01; OR1⁄40.67). Analysis, using Cox model supported these findings. Conclusions: Vaccination against pneumonia (alone or together with flu shot) could be a promising new candidate for repurposing in AD prevention, potentially acting through improving resilience of the immune system in the elderly. Further testing and validation of these effects in other human data is warranted. The study was supported by NIH grants R56AG059428 and R01AG046860.