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P4‐412: SEX‐DIFFERENCES IN THE ASSOCIATION OF BLOOD PRESSURE AND INCIDENT MCI IN MIDDLE‐ AND OLD‐AGED PARTICIPANTS
Author(s) -
Tebrügge Sarah,
Winkler Angela,
Müller-Gerards Diana,
Abramowski Jessica,
Moebus Susanne,
Jöckel Karl-Heinz,
Erbel Raimund,
Weimar Christian,
Jokisch Martha
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4084
Subject(s) - medicine , blood pressure , poisson regression , dementia , body mass index , population , demography , stroke (engine) , middle age , cardiology , disease , sociology , mechanical engineering , environmental health , engineering
criteria [2]. Results: One hundred and thirty-eight cases of incident dementia occurred during 7109 person-years of follow-up. The incidence rate was 19.4 (95% CI: 16.2-22.7) per 1000 person-years. Cox regression model indicated that, after adjusting for age, sex, education years, APOE-e4 allele, and baseline MMSE score, baseline MET 10.5 hour/week was associated with lower risk of dementia in comparison with MET <10.5 hour/week (HR, 0.52; 95% CI, 0.35-0.77). Participants who performed MVPA would have 45% lower risk of incident dementia compared to those who performed mild PA (HR, 0.55; 95% CI, 0.37-0.82). Conclusions: Moderate to vigorous physical activity may be of benefit to reduce dementia risk among Chinese older adults.