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P4‐362: DOMAIN‐SPECIFIC COGNITIVE IMPAIRMENT AND LONGITUDINAL COGNITIVE DECLINE DIFFER IN PARKINSON'S DISEASE DEMENTIA (PDD), DEMENTIA WITH LEWY BODIES (DLB), AND ALZHEIMER'S DISEASE (AD)
Author(s) -
Smirnov Denis,
Galasko Douglas R.,
Filoteo J. Vincent,
Edland Steven D.,
Hansen Lawrence A.,
Salmon David P.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4033
Subject(s) - dementia with lewy bodies , dementia , lewy body , parkinsonism , psychology , cognition , cognitive decline , neuropsychology , disease , psychiatry , medicine , audiology , clinical psychology , pathology
diagnosis was corroborated by a cognitive neurologists specialist. The groups were matched according to age, years of education, gender, Beck inventory and functional activities scale (FAQ). Demographic, neurological and complementary studies were analyzed. A complete neuropsychological assessment and a battery of SC were administered, which included Eyes test (ET), Faux Pas Recognition Test (FPRT), Hotel Test (HT), facial expressions test, mini-SEA and TASIT. Parametric, non-parametric and Pearson correlation statistics were used. Results: Significant differences were observed between the groups (ANOVA) in the FPRT (p 1⁄4 0.02), with the NDD group having the lowest result (mean: 16.47 6 6.3) after the post-Hoc analysis (Bonferroni). There were no significant differences between the means of other tests. In HT, the highest values of involvement (80%) were found in the MC group, justifying executive dysfunction and failures in prospective memory. Interestingly, both the NDD group and the FBL had a significant correlation between ET and the number of tasks performed in the TH; however, in the first, it was direct (r 1⁄4 + 0.48, p 1⁄4 0.01) and in the second inverse (r 1⁄4 -0.79, p 1⁄4 0.01). Also, in FBL group had a positive correlation between ETand episodic verbal learning and phonological fluency, while in NDD and MC groups had both ET and FPRT positive correlations with other neuropsychological tests (NPS). Conclusions: The present work demonstrates the clinical utility of a SC evaluation. In the present sample, patients with NDD disease presented worse performance in FPRT. Furthermore, the positive correlations between SC tests and other NPS tests may contributes to understand more the complex SC network.