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P4‐348: VENOUS COLLAGENOSIS AS PATHOGENESIS OF WHITE MATTER HYPERINTENSITIES
Author(s) -
Lahna David,
Boespflug Erin L.,
Woltjer Randall L.,
Schwartz Daniel,
Black Sandra E.,
Roese Natalie,
Keith Julia,
Gao Fuqiang,
Ramirez Joel,
Silbert Lisa C.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4018
Subject(s) - hyperintensity , medicine , masson's trichrome stain , trichrome , white matter , anatomy , pathology , lumen (anatomy) , cardiology , magnetic resonance imaging , radiology , fibrosis , h&e stain , staining
with t-tau (B1⁄4.009, p1⁄4.009) and p-tau (B1⁄4.008, p1⁄4.037), but not with Ab42 (B1⁄4.005, p1⁄4.183). Posthoc analyses revealed that the observed relationships were more marked in older participants ( 61 years of age; t-tau: B1⁄4.018, p1⁄4.001; p-tau: B1⁄4.014, p1⁄4.007) compared with younger participants (<61 years of age; ps > .05). Conclusions: Our findings indicate that high cardiac workload at rest is related to higher levels of t-tau and p-tau, but not Ab42, in cognitively normal late-middle-aged adults; and that older age exacerbates this adverse linkage. This suggests that high myocardial oxygen demand at rest—especially within the context of advancing age—either promotes or co-occurs with alterations in tau, but not with brain amyloidosis. Longitudinal studies would be needed for further establishing causality in these associations.