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P4‐346: FEATURES OF THE EXPRESSION OF INDUCIBLE NO SYNTHASE IN THE HUMAN HIPPOCAMPUS WITH THE INITIAL MANIFESTATIONS OF VASCULAR DEMENTIA IN ATHEROSCLEROSIS OF THE CEREBRAL ARTERIES
Author(s) -
Gorelik Elena Vladimirovna,
Smirnov Alexey Vladimirovich,
Krayushkin Alexander Ivanovich,
Ekova Maria,
Grigoryeva Natalya Vladimirovna,
Guski Hans
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4016
Subject(s) - hippocampus , neuropil , hippocampal formation , vascular dementia , cerebral arteries , medicine , cerebral atherosclerosis , endocrinology , pathology , biology , dementia , anatomy , central nervous system , disease
were extracted using an automated tissue segmentation method, and cerebral blood flow through the carotids was measured by 2D phase-contrast. We compared hemispheres within individuals for volumetric measures and microstructural integrity. Results: Among 50 eligible participants (mean age 76 years, 50% women), median grade of stenosis on the affected side was 57% (IQR 51-65%). Flow was on average lower in the affected carotid artery (160 mL/min versus 202 mL/min on the unaffected side; P1⁄40.0002), with larger flow reductions with higher degree of stenosis (reduction in flow [95% CI] per 1% increase in stenosis 1⁄4 1.7 mL/min [1.0-2.5], P<0.0001). Downstream of the stenotic artery, parenchymal volume was smaller than in the contralateral hemisphere (mean difference [95% confidence interval] -2.7 mL [-4.9;-0.4]), similar for grey and white matter, and unaffected by excluding individuals with prior TIA or stroke. Differences were most profound in the frontoparietal lobes, and increased with severity of stenosis to roughly 5 mL in individuals with 70% stenosis. White matter hyperintensity volume and microstructural integrity did not differ between hemispheres. Conclusions: Carotid artery stenosis is associated with parenchymal tissue loss, with effects equivalent to 1-2 years of brain ageing.