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P4‐339: ASSOCIATION OF CORNEAL NERVE FIBER MEASURES WITH COGNITIVE FUNCTION IN DEMENTIA
Author(s) -
Ponirakis Georgios,
Al Hamad Hanadi,
Sankaranarayanan Anoop,
Khan Adnan,
Chandran Mani,
Ramadan Marwan,
Tosino Rhia,
Gawhale Priya,
Alobaidi Maryam,
AlSulaiti Essa,
Elsotouhy Ahmed,
Elorrabi Marwa,
Khan Shafi,
Nadukkandiyil Navas,
Osman Susan,
Thodi Noushad,
Almuhannadi Hamad,
Gad Hoda,
Mahfoud Ziyad,
Petropoulos Ioannis,
Own Ahmed,
Al Kuwari Maryam,
Shuaib Ashfaq,
Malik Rayaz A.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.4009
Subject(s) - dementia , medicine , amyotrophic lateral sclerosis , ophthalmology , nerve fiber , cognition , cognitive decline , audiology , disease , anatomy , psychiatry
Background: Frontotemporal lobar degeneration (FTLD)-related syndromes can be associated with abnormal tau (tauopathy), transactive response DNA binding protein 43 kDa (TDP-43 proteinopathy) or Alzheimer’s disease (AD). Progressive supranuclear palsy (PSP) is usually a tauopathy. Corticobasal syndrome can be due to AD. Semantic variant primary progressive aphasia (svPPA) and amyotrophic lateral sclerosis (FTD-ALS) are usually TDP-43 proteinopathy. Our aim was to compare white matter (WM) integrity between tauopathies and TDP-43 proteinopathies and relate the WM integrity to neuropsychological assessments. Methods: Twenty-two patients [9 males, 13 females; age (66.7366.27); diagnoses (5 CBS-AD, 4 FTD-ALS, 9 PSP, 1 PSP-AD, 3 svPPA)] were recruited for this study. The whole cohort was divided into tauopathies [N1⁄415; diagnoses (5 CBS-AD, 9 PSP, 1 PSP-AD)], and TDP43 proteinopathies [N1⁄47; diagnoses (4 FTD-ALS, 3 svPPA)]. Seed-based probabilistic tractography was performed to analyze white matter integrity. Cerebrospinal fluid analysis was performed to assess for the presence of AD pathology. Language testing was completed. Results: The tauopathy [age (67.6065.33)] and TDP43 proteinopathy [age (64.8668.07)] groups were not significantly different in age (p>0.6). The left uncinate tract (LUNC) mean diffusivity (MD)[1.10x1060.1x10 vs. 1.00x1060.06x10 mm/s; p1⁄40.017], axial diffusivity (AD) [1.50x1060.1x10 vs. 1.30x1060.05x10 mm/s; p1⁄40.014], and radial diffusivity (RD) [1.00x1060.1x10 vs. 0.80x1060.06x10 mm/s; p1⁄40.022] were significantly higher in the TDP-43 proteinopathy group. For the patients able to complete the language assessments (N1⁄417), LUNC MD (r1⁄4-0.762;p1⁄40.001), AD (r1⁄40.695;p1⁄40.004), and RD (r1⁄4-0.744;p1⁄40.001) were significantly correlated with naming on MINT task, controlled for age and education. For the Northwestern Naming Battery the noun subtest (N1⁄418) was significantly correlated with LUNC MD (r1⁄40.754;p1⁄40.001), AD (r1⁄4-0.765;p1⁄40.001), and RD (r1⁄40.697;p1⁄40.003), controlled for age and education. The verb subtest (N1⁄418) showed a trend with LUNC MD (r1⁄4-0.496;p1⁄40,051), AD (r1⁄4-0.463;p1⁄40.071), and RD (r1⁄4-0.480;p1⁄40.060), controlled for age and education. Conclusions: The TDP-43 proteinopathy group had decreased WM integrity in the LUNC tract compared with the tauopathy group. The LUNC is implicated in semantic language and decreased integrity was associated with worse language scores. The LUNC integrity may be useful for differentiating tauopathies from TDP-43 proteinopathies.