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P4‐312: LONGITUDINAL PET MEASURES OF TAU AND AMYLOID ACCUMULATION IN AUTOSOMAL DOMINANT ALZHEIMER'S DISEASE: FINDINGS FROM THE COLBOS PROJECT
Author(s) -
Sanchez Justin S.,
Lopera Francisco,
Sperling Reisa A.,
Becker Alex,
Artola Arabiye,
Baena Ana,
Jacobs Heidi I.L.,
Hanseeuw Bernard J.,
Schultz Aaron P.,
Gatchel Jennifer R.,
Katz Samantha,
Mayblyum Danielle,
Moody Kirsten,
Price Julie C.,
Bocanegra Yamile,
Guzman-Velez Edmarie,
Pardilla-Delgado Enmanuelle,
Vila-Castelar Clara,
Martinez Jairo,
Fuller Joshua,
Reiman Eric M.,
Johnson Keith A.,
Quiroz Yakeel T.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.3982
Subject(s) - psen1 , precuneus , presenilin , medicine , alzheimer's disease , disease , cardiology , pathology , oncology , neuroscience , psychology , nuclear medicine , cognition
declines in any cognitive domain, global cognition or incident dementia. However, when dichotomised into a binary variable, there were differential associations by brain area. Participants with the most severe BG PVS had greater declines in attention and processing speed and participants with the most severe CSO PVS had greater declines in global cognition, after adjusting for all covariates. Those with severe CSO PVS also had a higher rate of incident dementia, but this failed to achieve significance after adjusting for other neuroimaging markers. Conclusions: There may only be cognitive implications for those with the most severe PVS pathology. There are differential associations for BG and CSO PVS and cognition, which may represent differences in their underlying pathology.