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P4‐310: ALTERATIONS OF INTRINSIC CONNECTIVITY IN POSTERIOR DEFAULT MODE NETWORK ACROSS AT RISK STAGES OF ALZHEIMER'S DEMENTIA
Author(s) -
Hu Xiaochen,
Lee Hwee Ling,
Spottke Annika,
Peters Oliver,
Priller Josef,
Bürger Katharina,
Teipel Stefan J.,
Laske Christoph,
Wiltfang Jens,
Düzel Emrah,
Jessen Frank
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.3980
Subject(s) - default mode network , posterior cingulate , precuneus , neuroscience , dementia , resting state fmri , psychology , cognition , correlation , medicine , audiology , disease , geometry , mathematics
p-tau was associated with MWF across several bilateral white matter tracts (Table). Change in PACC (b1⁄4-2.21, p1⁄4.047) was associated with MWF change in left cingulum projecting to cingulate gyrus; no effects in other tracts reached significance. Conclusions: Across several tracts, higher p-tau was associated with MWF decreases, suggesting that myelin degeneration and development of tangle pathology are longitudinally associated. A positive longitudinal slope on PACC was associated with decreasing MWF, although the significant effect was limited to left cingulum. Additional studies are needed to elucidate the relationship between myelin degeneration, accruing pathology, and cognitive function.