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P4‐299: PHOSPHORYLATION OF SPECIFIC TAU SITES IS ASSOCIATED WITH LOSS OF WHITE MATTER INTEGRITY IN AUTOSOMAL DOMINANT ALZHEIMER DISEASE
Author(s) -
Strain Jeremy F.,
Wisch Julie,
Kilgore Collin B.,
Mcdade Eric,
Li Yan,
Barthélemy Nicolas R.,
Gordon Brian A.,
Hassenstab Jason,
Fagan Anne M.,
Bateman Randall,
Ances Beau M.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.3968
Subject(s) - white matter , fractional anisotropy , diffusion mri , voxel , chemistry , pathology , magnetic resonance imaging , neuroscience , psychology , medicine , radiology
All data were successfully quantified with both Tau (TauL: 35 +/29%, 45% of cases exhibited a local tau component, see Figure 3) and SUVR (1.07 +/0.1). The correlation between TauL and clinical scores (MMSE: r1⁄4 -0.59, ADAS-COG: r1⁄4 0.60) was stronger than with SUVR (MMSE: r 1⁄4 -0.47, ADAS-COG: r 1⁄4 0.49). TauL was also more highly correlated with CSF tau (r 1⁄4 0.53) than SUVR (r 1⁄4 0.45). Conclusions: Tau demonstrates a stronger relationship with cognitive and CSF assessments than existing analysis approaches offering an improved biomarker for tracking tau pathology in clinical trials.