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P4‐269: DISTRIBUTION PREPONDERANCE OF CEREBRAL MICROBLEEDS ACCORDING TO SEVERITY OF LEUKOARAIOSIS IN AD
Author(s) -
Park Mee Young,
Shin Dong Seung
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.3938
Subject(s) - leukoaraiosis , medicine , cardiology , neuropsychology , cerebral infarction , disease , cognition , ischemia , psychiatry , dementia
Background: Cerebral microbleeds (CMBs) and leukoaraiosis (LA) are common findings in Alzheimer’s disease (AD). But clinical or topographic relation of CMBs associated with LA in AD has been lacking. This study was performed to determine frequency and topographic preponderance of CMBs according to severity of LA in AD and compare the cognition and behavior of the AD patients according to severity of LA in AD, also. Methods: Patients with uncontrolled hypertension and cases with cerebral infarction and Parkinson’s disease were excluded. 101 AD patients were classified in three groups as patients with minimal LA (n1⁄455), moderate LA (n1⁄430) and with severe LA (n1⁄416). This study was carried out in minimal group and moderate-severe group. Demographic characteristics were not statistically significant differences in Age, Sex, Education, hypertension, K-MMSE, and CDR score between the two groups. The Microbleed Anatomical Rating Scale (MARS) was used to localize each CMB location. CMBs were counted using mainly 1.5 Tesla SWI (n1⁄490) and gradient-echo (n1⁄410) imaging. Classification of cerebral white matter hyperintensities in CREDOS study. Results: Numbers and location of CMBs in moderate to severe LA group were statistically compared with those of CMBs in minimal LA group. Moreover, we compared neuropsychology between the two groups by Seoul Neuropsychological Battery-1. Total CMBs in moderate to severe LA group (CMBs 1⁄4 77) was significantly more than CMBs (CMBs1⁄432) in minimal LA group (P1⁄40.024*, T-test). There is not distribution predominance of CMBs in AD according to leukoaraiosis (P1⁄40.775x, Chi-square test). Conclusions: As LA progresses, total number of CMBs increases without affecting cognition and behavior in AD patients. But these findings suggest there is not distribution predominance of CMBs in AD according to leukoaraiosis.