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P4‐265: NEUROCHEMICAL CORRELATES OF COGNITIVE DYSFUNCTION IN PATIENTS WITH LEUKOARAIOSIS: A PROTON MAGNETIC RESONANCE SPECTROSCOPY STUDY
Author(s) -
Yuan Junliang
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.3934
Subject(s) - leukoaraiosis , white matter , psychology , medicine , neurochemical , hyperintensity , magnetic resonance imaging , radiology
and non-demented participants (mean age 73.1 years, 54.3% women) of the prospective population-based Rotterdam Study were included. The participants underwent brain MRI (1.5 tesla) in 2005-2011 and were followed for stroke, dementia and death until 2016-2017. The presence of four MRI markers (strictly lobar cerebral microbleeds, cortical superficial siderosis, centrum semiovale perivascular spaces, and white matter hyperintensities) were combined to construct the CAA sum score. We used Cox proportional hazards models to determine the association of the CAA score with risk of stroke, dementia and mortality, adjusting for age and sex. Additionally, we examined competing risks from death due to other causes for stroke and dementia. Results: During a mean follow-up of 7.2 years, 62 participants developed stroke, 77 developed dementia and 298 died. The age and sex adjusted hazard ratios (HRs) per point increase of the sum score were 1.41, 95% CI (0.992.00) for stroke; HR 1.19, 95%CI (0.86-1.65) for dementia; and HR 1.26, 95% CI (1.07-1.48) for mortality. No significant differences were seen for subdistribution HRs for both stroke and dementia. Conclusions: A higher CAA sum score is related to higher risk of stroke, dementia and death in our community-dwelling population. The composite CAA score can be a practical indicator to capture the severity of vascular brain injury.