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P4‐263: SUM SCORE OF CEREBRAL AMYLOID ANGIOPATHY IS ASSOCIATED WITH STROKE, DEMENTIA AND DEATH: THE ROTTERDAM STUDY
Author(s) -
Yilmaz Pinar
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.3932
Subject(s) - cerebral amyloid angiopathy , dementia , stroke (engine) , medicine , superficial siderosis , hazard ratio , proportional hazards model , population , rotterdam study , hyperintensity , lacunar stroke , magnetic resonance imaging , prospective cohort study , cardiology , confidence interval , radiology , disease , ischemic stroke , ischemia , engineering , mechanical engineering , environmental health
participants include Animal Naming (ANIMAL), Trail Making A test (TMA), the Selective Reminding Test containing the Free Recall (SRTFREE) and the Mini-Mental State Examination (MMSE). NII was acquired with multi-b value scheme (bmax 1⁄41400s/mm and 25 directions). NII derived edema fraction (reflectingWM vasogenic edema) was quantified and correlated with cognitive tests using tract-based spatial statistics. Results: There is an elevation of NII derived edema fraction in the iAD group but not in the PC group when compared to the HC group (Figure 1). The significant correlations between NII edema fraction and ANIMAL, TMA and MMSE, but not SRTFREE have been observed (Figure 2). Scatter plots demonstrated those associations on corpus callosum tract as a representative example (Figure 3). Conclusions: Our findings suggest the presence of WM vasogenic edema in incipient AD, which could be used as a predictor for cognition decline. As a non-invasive imaging tool, NII hold a promise in detecting WM vasogenic edema and investigating its association with cognitive measures. P4-262 COGNITIVELY SUPERNORMAL OLDER ADULTS MAINTAIN A UNIQUE STRUCTURAL CONNECTOME THAT IS RESISTANT TO ALZHEIMER’S PATHOLOGY