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P4‐256: SAFETY OF DONEPEZIL HYDROCHLORIDE 10MG/DAY IN CHINESE MILD TO MODERATE ALZHEIMER'S DISEASE PATIENTS
Author(s) -
Jia Jianping,
Wei Cuibai,
Zhou Aihong,
Wang Fen,
Tang Yi
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.3925
Subject(s) - donepezil , medicine , nausea , adverse effect , vomiting , incidence (geometry) , anesthesia , disease , dementia , physics , optics
the observed variable importance (oVI) associated with participant baseline CFI was 0.13 (95%CI: 0.11, 0.14), compared to 0.19 (95% CI: 0.18, 0.21) for informant baseline CFI. Among non-spousal dyads, the oVI for participant baseline CFI was 0.37 (95%CI: 0.35, 0.41) compared to 0.07 (95%CI: 0.06, 0.11) for informant CFI. In cross-sectional models, oVI was 0.08 (95% CI: 0.07, 0.09) for participant and 0.21 (95% CI: 0.19, 0.23) for informant CFI among spousal dyads and 0.17 (95% CI: 0.16, 0.18) for participant and 0.10 (95% CI: 0.09, 0.11) for informant CFI among nonspousal dyads. Conclusions: Qualified informants provide useful information regarding cognitive status and future decline. However, the quality of information from non-spousal informants appears to provide less accurate information regarding cognitive state compared to that of spousal informants.