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P2‐594: ESTIMATE OF CASES ATTRIBUTABLE TO MODIFIABLE RISK FACTORS FOR DEMENTIA WITHIN A POPULATION‐BASED SAMPLE IN ITALY: THE INVECE.AB STUDY
Author(s) -
Rolandi Elena,
Zaccaria Daniele,
Vaccaro Roberta,
Abbondanza Simona,
Poloni Tino Emanuele,
Davin Annalisa,
Medici Valentina,
Chikhladze Maia,
Guaita Antonio
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.3003
Subject(s) - dementia , medicine , attributable risk , population , risk factor , gerontology , demography , depression (economics) , cohort , loneliness , cohort study , psychiatry , environmental health , disease , sociology , economics , macroeconomics
relationships with SES and brain volume (all p<.05). A Sobel mediation analysis determined smoking significantly mediated the relationship between SES and brain volume (Figure 2; p1⁄4.016). With respect to brain volume, smoking accounted for a significant amount of variance (b1⁄4-.116 SE1⁄4.065; p1⁄4.01) that was previously attributed to SES. Conclusions: Targeting SES disparities could be a promising means to improve brain health and may decrease vulnerability for AD. Notably, smoking appears to partly explain the adverse effects of low SES on brain volume.