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P2‐569: DEPRESSION ASSOCIATED WITH GREATER ODDS OF DEMENTIA IN SEXUAL MINORITY OLDER ADULTS
Author(s) -
Flatt Jason D.,
Johnson Julene K.,
Gilsanz Paola,
Ranatunga Dilrini,
Fredriksen-Goldsen Karen,
Whitmer Rachel A.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2978
Subject(s) - dementia , depression (economics) , sexual minority , odds ratio , medicine , odds , logistic regression , psychiatry , confidence interval , lesbian , gerontology , demography , psychology , disease , economics , sociology , psychoanalysis , macroeconomics
the risk of incident dementia and clinical AD. MIND diet scores were examined as a continuous variable and according to tertiles [TI:1.8-6.0; T2:6.2-7.5; T3:7.7-11.7]. Results: After adjustment for age, sex, calorie intake, physical activity, vascular risk factors, and presence of ApoE4 allele, each unit increase in the MIND diet score was associated with a decreased risk of all-cause dementia (hazard ratio, 0.86[95%CI,0.75,0.98]), and AD (0.85[0.73,0.99]). Persons with MIND diet scores in the top (0.47[0.27,0.82]) but not middle tertile (0.82[0.51,1.31]) had a lower risk of all-cause dementia, as compared to the bottom tertile. Participants with MIND diet scores in the top (0.46[0.24,0.89]) but not middle tertile (0.78 [0.44,1.37]) also had a lower risk of AD, as compared to the bottom tertile. We did not observe any effect modification by ApoE4 status. Conclusions: Higher adherence to the MIND diet was independently associated with lower risk of all-cause dementia and clinical AD. Further studies are needed to elucidate whether adopting the MIND diet can alter cognitive trajectories with aging.