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P2‐561: STRESS LEVEL IS ASSOCIATED WITH ALZHEIMER'S DISEASE CSF BIOMARKERS AND COGNITION ESPECIALLY IN AFRICAN AMERICANS WITH MILD COGNITIVE IMPAIRMENT
Author(s) -
Hajjar Ihab,
Thomas Tiffany,
Shaw Leslie M.,
Goldstein Felicia C.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2970
Subject(s) - perceived stress scale , cognition , montreal cognitive assessment , medicine , clinical dementia rating , psychology , dementia , clinical psychology , cohort , disease , gerontology , stress (linguistics) , psychiatry , philosophy , linguistics
125), s-AD (n1⁄4 81) and non-case (n1⁄4 4284) at baseline. Dementia was determined based on a clinical assessment and diagnosis of AD using DSM-III-R and NINCDS-ADRDA criteria. Family history of memory problems was obtained via interview. Family history and time to dementia or right censoring was modeled using Cox proportional hazards regression in separate models for each sex. Covariates tested were educational attainment, age and presence of APOE E4 allele. Results: In males, baseline cognitive status of CIND was associated with an increased risk of all-cause dementia (HR1⁄4 3.96, p<.001) and AD (HR 1⁄4 4.51, p <.001) and s-AD was associated with increased risk of all-cause dementia (HR 1⁄4 3.52, p 1⁄4<.001) and AD (HR1⁄4 6.04, p< .001) compared to non-cases. In females, CIND at baseline was associated with an increased risk of all-cause dementia (HR1⁄4 2.70, p<.001) and AD (HR1⁄4 9.63, p< .001), while a status of baseline s-AD increased the risk of all-cause dementia (HR 1⁄4 6.51, p <.001) and AD (HR 1⁄4 7.21, p <.001), compared to non-cases. Family history did not modify risk in either males or females. Conclusions: Males and females with a baseline status of CIND or s-AD are at increased risk of all-cause dementia and AD. Family history of AD or memory problems did not predict conversion to type of dementia.