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P2‐558: MEASUREMENT OF COGNITIVE HEALTH IN DIVERSE OLDER ADULTS: THE KAISER HEALTHY AGING AND DIVERSE LIFE EXPERIENCES (KHANDLE) STUDY
Author(s) -
Mungas Dan M.,
Saucedo Hector Hernandez,
Whitmer Rachel A.,
Glymour Maria,
DeCarli Charlie S.,
Bhulani Nihal,
Miles Sunita,
Gilsanz Paola
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2967
Subject(s) - dementia , gerontology , medicine , cognition , cognitive decline , cognitive test , population , neuropsychology , cohort , ethnic group , clinical psychology , psychiatry , disease , environmental health , pathology , sociology , anthropology
and visual inspection of all medications. Use of any sleep medication (time-varying) and time to dementia or right censoring was modeled using Cox proportional hazards regression in separate models for males and females. Covariates tested were sleep disturbance, depression status, age, presence of APOE E4 allele, and educational attainment. Results: In men, use of sleep medication was associated with 3.6 times increased risk of developing AD (HR1⁄43.604, p 1⁄4 0.0001) compared to those who did not use sleep medications. In women, risk of AD varied by endorsement of a sleep disturbance: women who did not endorse a sleep disturbance but used sleep medications were nearly 4 times at greater risk for developing AD (3.916; p 1⁄4 .0001) whereas those without sleep disturbance and who used sleep medications were at a 35.2% reduced risk of developing AD. Conclusions: Caution is warranted in prescribing sleep medications for older adults, though effects in AD risk vary by sex and endorsement of sleep disturbance. Further research is needed to determine the mechanisms underlying the observed sex differences.