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P2‐556: AGENT ORANGE EXPOSURE AND DEMENTIA DIAGNOSIS IN VIETNAM VETERANS: A CHRONIC EFFECTS OF NEUROTRAUMA CONSORTIUM STUDY
Author(s) -
Barnes Deborah E.,
Li Yixia,
Byers Amy L.,
Gardner Raquel C.,
Peltz Carrie,
Yaffe Kristine
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2965
Subject(s) - medicine , agent orange , dementia , medical record , retrospective cohort study , diabetes mellitus , psychiatry , cohort , disease , endocrinology , archaeology , history
and occupational attainment as formative latent variables of CR. We examined whether the resulting CR measure (median-split) modified ADRD risk associated with residing in locations exceeding the US National Ambient Air Quality Standard (3-year average PM2.5 >12 vs. 12 mg/m), adjusting for potential confounders, with proportional hazards regression. Results: Among 6113 women, 262 were classified as incident cases of ADRD (average follow-up 8.8 years). Residing in locations with high PM2.5 was associated with increased ADRD risk (hazard ratio [HR]1⁄41.70; 95% CI [1.31, 2.22]), adjusting for geographic region, age, socioeconomic characteristics, lifestyle, clinical characteristics, and hormone therapy. This putative neurotoxic effect of PM2.5 was much greater (interaction p1⁄40.01) among older women with lower educational attainment ( high school; HR1⁄42.58, [1.66, 4.02]) compared to their counterparts (> high school; HR1⁄41.35; [0.99, 1.85]). Although non-significant, low CR was associated with increased ADRD risk (HR1⁄41.23; [0.90, 1.68]). The adverse effect of PM2.5 was much greater (interaction p1⁄40.02) among women with low CR (HR1⁄42.13; [1.51, 2.99]) than among women with high CR where the association was no longer significant (HR1⁄41.21; [0.82, 1.78]). Conclusions: Our novel findings support the hypothesis that high CR attenuates the PM2.5 neurotoxicity on brain aging.