P2‐525: TRAJECTORIES OF COGNITIVE DECLINE FROM THE PRODROMAL STAGE IN ALZHEIMER'S DISEASE AND RELATED DISORDERS: DATA FROM A REGIONAL ROUTINE CARE DATABASE

familial forms of dementia: North (New Delhi, AIIMS), South (Thiruvananthapuram, SCTIMST; Bengaluru, NIMHANS) and East (Kolkata, BIN). A standardized methodology will be employed to establish dementia diagnosis and study risk and protective factors. A centralized bio-bank at NBRC, Manesar will be developed where imaging biomarker and genetic studies will be carried out, with University of Calcutta. Results: Over four detailed workshops, the study methodology was finalized by a multidisciplinary team of 59 investigators (neurologists, epidemiologists, neuro-radiologists, neuropsychologists, biochemists, geneticists, biostatisticians, psychiatrists, social workers and physicians from 8 institutions (Fig.1). Dementia will be diagnosed using a standardized protocol consisting of instruments validated across five languages and literacy levels. Demographic, cardiovascular, dietary and life-course risk and protective factors for dementia appropriate for India will be studied. Care giver burden will also be determined. This will be supported by neuro-imaging biomarkers using an adapted ADNI protocol, biochemical and genetic studies. The methodology will be aligned with ongoing global studies. Conclusions: The multicentric dementia program will generate novel and indigenous evidence from India about dementia burden, risk and protection, that will help inform policies and programs related to dementia and the elderly. It will also help in guiding future research in low and middle-income country settings and elsewhere.