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P2‐524: AADAR DEMENTIA SCIENCE PROGRAM: METHODOLOGY OF A LONGITUDINAL MULTICENTRIC AND MULTIDISCIPLINARY COMMITMENT FROM INDIA FOR EPIDEMIOLOGY, CLINICAL CASE REGISTRY AND BASIC SCIENCE RESEARCH ON DEMENTIA AND RELATED DISORDERS
Author(s) -
Alladi Suvarna
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2932
Subject(s) - dementia , epidemiology , cohort , medicine , population , government (linguistics) , multidisciplinary approach , cohort study , gerontology , family medicine , psychiatry , environmental health , disease , pathology , social science , sociology , linguistics , philosophy
function using the Chinese version of the mini-mental state examination (MMSE). Cognitive impairment was defined by an MMSE score of less than 18 out of 30. Incidence rates were calculated using the person-years method. Cox proportional hazard models were performed to investigate trends in cognitive impairment incidence and its risk factors. Results: During a period of 86,975 person-years of follow-up, 3179 incidences of cognitive impairment were documented, the crude incidence rate was 38.3 per 1000 person-years for 2002-2008 cohort; and 34.6 for the 2008-2014 cohort. Cognitive impairment incidence decreased over time (adjusted HR per 6-year period, 0.88; 95% CI, 0.82-0.95), the absolute decrease was 3.7 per 1000 person-years overall; while the decrease was more prominent for younger elderly (65-79), with an adjusted HR per 6year period of 0.68 (0.58-0.80), than the oldest old. Hazards ratios of most risk factors in relation to their association with cognitive impairment remained similar across the time periods; while it was found declining hazards of cognitive impairment incidence for hypertension (I1⁄484.17, P1⁄40.012) over time, and increasing hazards for advancing age (I1⁄494.21, P<0.001 ). Conclusions: In this population-based cohort focusing on Chinese elderly, cognitive impairment incidence decreased from 2002 to 2014, and the decreases varied across age groups. While hazards for cognitive impairment risk factors remained fairly constant, detection of cognitive impairment ought to be enhanced through increased awareness coupled with risk factor-specific prevention. P2-524 AADAR DEMENTIA SCIENCE PROGRAM: METHODOLOGY OFA LONGITUDINAL MULTICENTRIC AND MULTIDISCIPLINARY COMMITMENT FROM INDIA FOR EPIDEMIOLOGY, CLINICAL CASE REGISTRYAND BASIC SCIENCE RESEARCH ON DEMENTIA AND RELATED DISORDERS