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P2‐464: QUALITATIVE ANALYSIS OF RECOGNITION MEMORY DEFICITS IN PRECLINICAL BEHAVIORAL VARIANT FRONTOTEMPORAL DEMENTIA IN MAPT CARRIERS
Author(s) -
Barker Megan,
Cheran Gayathri,
Manoochehri Masood,
Silverman Hannah,
Goldman Jill,
Huey Edward,
Cosentino Stephanie
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2871
Subject(s) - frontotemporal dementia , semantic memory , verbal fluency test , psychology , fluency , semantic dementia , neuropsychology , executive functions , cognitive psychology , cognition , recognition memory , audiology , dementia , neuroscience , medicine , disease , pathology , mathematics education
to identify patterns in sets of colored geometric shapes. MTL segmentation was performed in T1-weighted MRI using an analysis pipeline prescribed for subregional MTL measures, including anterior/posterior hippocampus, entorhinal cortex (ERC), BA35 (i.e. tansentorhinal cortex), BA36, and parahippocampus. Amyloid PET was dichotomized as positive or negative. Linear mixed-effects models related test scores to MTL measures and amyloid status. Results: Performance across semantic tasks differentiated MCI patients from CN participants (ps< 0.05). Integrity of MTL subregions vulnerable to earliest AD pathology, including BA35, predicted performance on the semantic tasks (Figures 1 and 2, ps < 0.01) in the CN group. Amyloid positive CN adults (i.e. preclinical AD; n1⁄412) displayed a trend of poorer performance on semantic tasks relative to amyloid negative CN adults (n1⁄427, p < 0.1). The visual-spatial analogy task didn’t differentiate groups, relate to MTL atrophy, or amyloid status, reflecting the specificity of the semantic tasks. Conclusions: These preliminary results confirm our hypothesis that probing semantic richness may differentiate healthy aging from preclinical AD and track neurodegeneration in earliest regions of tangle pathology (e.g. transentorhinal cortex).