P2‐459: EXECUTIVE CONTROL DEFICITS AS AN EARLY DIAGNOSTIC TO DEMENTIA OF ALZHEIMER'S TYPE

and were not moderated by APOE. Baseline ESQ was not associated with change in MIA (b1⁄4-0.001; Se1⁄40.001; p1⁄40.38) and no 3-way interaction with APOE was observed (b1⁄40.001; Se1⁄40.001; p1⁄40.51). However, lower baseline MQ scores were associated with MIA increases over time in E4-carriers but not in non-carriers (b1⁄4-0.003; Se1⁄40.001; p1⁄40.027) (Figure 2). Change in MQ was not differently associated with a change in MIA between carriers or non-carriers. Conclusions: These findings indicate that lower memory performance was associated with increases in worry about memory performance in E4-carriers only. Even though E4-carriers did not decline faster on memory than the non-carriers, it is known that carriers accumulate more amyloid and tau pathology. Therefore, other health or cognitive problems associated with higher AD pathology may explain why carriers endorse more complaints over time. P2-459 EXECUTIVE CONTROL DEFICITS AS AN EARLY DIAGNOSTIC TO DEMENTIA OF ALZHEIMER’S TYPE