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P2‐433: ASSOCIATION BETWEEN LIMBIC LESIONS (TDP‐43 AND/OR LEWY TYPE SYNUCLEINOPATHY) AND PSYCHOTIC SYMPTOMS IN PATIENTS WITH DEMENTIA: PRELIMINARY DATA FROM THE ABBIATEGRASSO BRAIN BANK (ITALY)
Author(s) -
Poloni Tino Emanuele,
Medici Valentina,
Negro Giulia,
Davin Annalisa,
Chikhladze Maia,
Zaccaria Daniele,
Vaccaro Roberta,
Rolandi Elena,
Abbondanza Simona,
Ceretti Arcangelo,
Ceroni Mauro,
Guaita Antonio
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2840
Subject(s) - vascular dementia , lewy body , dementia , pathology , neuropathology , psychology , medicine , parahippocampal gyrus , limbic system , hippocampus , alzheimer's disease , clinical dementia rating , parkinsonism , neuroscience , disease , temporal lobe , central nervous system , epilepsy
were observed mainly in the occipital cortex. Cerebral amyloid angiopathy was present throughout the brain. In the neocortex, tau pathology, especially neuropil threads were more abundant in the frontal and occipital cortex and in the hippocampus. No a-synuclein or TDP-43 pathology was found in cortical or subcortical areas. Conclusions: Here, we present the first comprehensive neuropathological study of early-onset FAD with a missense mutation Thr116Asn in the presenilin 1 gene. In contrast to other PS1-linked AD patients, the present subject developed cotton wool plaques which were not associated with spastic paraparesis.