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P2‐432: BRAINS BELONGING TO HOMOZYGOUS TWINS: CLINICOPATHOLOGICAL CORRELATIONS FROM GOLGI‐CENCI BRAIN BANK
Author(s) -
Medici Valentina,
Poloni Tino Emanuele,
Chikhladze Maia,
Davin Annalisa,
Vaccaro Roberta,
Rolandi Elena,
Abbondanza Simona,
Ceretti Arcangelo,
Guaita Antonio
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2839
Subject(s) - pathology , cerebral amyloid angiopathy , medicine , amyloid (mycology) , leukoaraiosis , white matter , dementia , magnetic resonance imaging , radiology , disease
were observed mainly in the occipital cortex. Cerebral amyloid angiopathy was present throughout the brain. In the neocortex, tau pathology, especially neuropil threads were more abundant in the frontal and occipital cortex and in the hippocampus. No a-synuclein or TDP-43 pathology was found in cortical or subcortical areas. Conclusions: Here, we present the first comprehensive neuropathological study of early-onset FAD with a missense mutation Thr116Asn in the presenilin 1 gene. In contrast to other PS1-linked AD patients, the present subject developed cotton wool plaques which were not associated with spastic paraparesis.