Premium
P2‐428: MYELOPROLIFERATIVE CONDITIONS IN OLDER ADULTS WITH MAJOR NEUROCOGNITIVE DISORDERS: IS THERE AN ASSOCIATION?
Author(s) -
Taiwo Tolulola O.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2835
Subject(s) - neurocognitive , dementia , medicine , cognition , thrombocytosis , psychiatry , pediatrics , disease , platelet
significant results (p<.05) from the ANOVA analyses were followed by post-hoc analyses using Tukey’s Honestly Significant Difference (HSD) test.Results: Mean SUVRswere not different between Hispanics (1.3860.27) and WNH (1.4260.33). However, there was a significant interaction between Hispanic ethnicity and E4 carrier status (F1,1321⁄44.79; p1⁄4.03), such that E4+ WNH subjects tended to have higher SUVRs than E4+ Hispanics, whereas E4Hispanics tended to have higher SUVRs than non-Hispanics. Conclusions: Genetic studies on Hispanics suggest that the effect of APOEε4 on AD risk may be less than that in Caucasians (Farrer et al., 1997, Tang et al., 1998, Ertekin-Taner, 2007). Our findings of a weaker influence of E4+ on amyloid load in Hispanics, as compared to WNHs appears to be consistent with results of studies suggesting that non-genetic risk factors for AD play a greater role among Hispanics, as compared to WNH Caucasians.