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P2‐416: INTRACRANIAL ARTERIOSCLEROSIS AND BRAIN STRUCTURE IN AGING
Author(s) -
Vinke Elisabeth J.,
Yilmaz Pinar,
Fakhry Rahman,
Frenzen Kilian,
Licher Silvan,
Kavousi Maryam,
Ikram M. Arfan,
Vernooij Meike W.,
Bos Daniel
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2823
Subject(s) - medicine , arteriosclerosis , quartile , dementia , cardiology , magnetic resonance imaging , brain size , calcification , atrophy , hyperintensity , radiology , stroke (engine) , neuroimaging , nuclear medicine , disease , confidence interval , mechanical engineering , psychiatry , engineering
including age and sex as covariates. Results: Lower mean blood flow and higher PI in major cerebral arteries were associated with significantly altered left (Figure 1, Table 1) and right (Figure 2, Table 2) WMM, suggesting white matter injury. Effects in the left hemisphere were particularly robust. Conclusions: These findings suggest that impaired blood flow and higher pulsatility in major cerebral arteries is associated with WMM injury in a cognitively unimpaired late middle-aged cohort. Lower FA and NDI and higher MD point toward a loss of white matter neurite density in the context of impaired cerebral flow dynamics. Effects were more pronounced in the left hemisphere, suggesting a potential lateralized vulnerability. Longitudinal assessment will be needed to strengthen causal inferences.