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P2‐411: EFFECTS OF ANTICHOLINERGIC BURDEN ON GREY BRAIN MATTER VOLUMES IN A POPULATION‐BASED COHORT ACROSS THE ENTIRE ADULT AGE RANGE
Author(s) -
Kilimann Ingo,
Katharina Wittfeld,
Wucherer Diana,
Ittermann Till,
Voelzke Henry,
Hoffmann Wolfgang,
Teipel Stefan J.,
Grabe Hans J.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2818
Subject(s) - anticholinergic , dementia , medicine , cohort , basal forebrain , hippocampus , population , psychology , cholinergic , disease , environmental health
calculated the relative risk (RR) of certain factors on increased global WMH burden in 277 cognitively healthy ACONF participants (mean age1⁄4 62.3). Global WMH burden was measured as total WMH volume (ml) using an automated WMH segmentation algorithm.We investigated potential risk factors within the domains of demographics, early-life, medical history, socioeconomic circumstance, late-life objective health, and late-life cognition. Results: We identified elevated risk factors for increased global WMH burden among each domain mentioned above. The most significant risk factors for increasedWMHburden in this cohort includedmedical histories of stroke (RR 1⁄4 2.642, 95% CI 1⁄4 1.59 – 4.39), heart disease (RR 1⁄4 1.864, 95% CI 1⁄4 1.098 – 3.165), diabetes (RR 1⁄4 1.903, 95% CI 1⁄4 1.194 – 3.032), and high cholesterol (RR 1⁄4 1.566, 95% CI 1⁄4 1.077 – 2.277). Notable earlyand mid-life risk factors approaching significance included birth weight of less than 5.5lbs (RR 1⁄4 1.697, 95% CI 1⁄4 .913 – 3.153) and working in lower-income occupations (RR 1⁄4 1.049, 95% CI 1⁄4 .715 – 1.538). Conclusions: We were able to confirm age and cardiometabolic risk factors for increased WMH burden in a relatively young cohort of older adults, and add contributions of emerging early and mid-life risk factors. Many of these cardiometabolic risk factors have their origins in early life and are greatest in thosewith the least resilience. Future work will involve developing a robust model of riskand protective determinants of WMH burden.