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P2‐405: AMPLITUDE‐ AND FLUCTUATION‐BASED DISPERSION ENTROPY FOR THE ANALYSIS OF RESTING‐STATE MAGNETOENCEPHALOGRAM IRREGULARITY IN MCI AND ALZHEIMER'S DISEASE PATIENTS
Author(s) -
Azami Hamed,
Escudero Javier,
Fernandez Alberto,
Arnold Steven E.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2812
Subject(s) - sample entropy , approximate entropy , magnetoencephalography , resting state fmri , entropy (arrow of time) , amplitude , neuroscience , randomness , medicine , physics , pattern recognition (psychology) , mathematics , electroencephalography , artificial intelligence , psychology , computer science , statistics , optics , quantum mechanics
lateral orbitofrontal cortex (voxel p<.001, cluster k>50). Next, in pairwise comparisons with the OA group, nAChR binding in VCIND was lower in bilateral anterior cingulate, whereas binding in MCI was lower in right medial temporal cortex. nAChR binding in the VCIND group was lower than in MCI in bilateral anterior cingulate (voxel p<.01, cluster k1⁄4440) (Figure). Results were not substantially different when DRS total score or age were included in the models. Conclusions: nAChR binding is reduced in VCIND, despite the modest level of cognitive decline. The magnitude of nAChR binding reduction in VCIND exceeds that of MCI in the anterior cingulate, likely related to regionally disrupted white matter tracts or local ischemia. The adverse clinical consequences of small-vessel cerebrovascular alterations, in concert with an early neurodegenerative process, may be driven by a leveraged cholinergic deficit in critical brain structures.