Premium
P2‐404: CHOLINERGIC RECEPTOR BINDING IN MCI WITH CEREBROVASCULAR DISEASE: 2‐FA PET IMAGING IN VIVO
Author(s) -
Sultzer David L.,
Veliz Joseph,
Gordon Hailey L.,
Hasratian Arpi S.,
Melrose Rebecca J.
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2811
Subject(s) - medicine , binding potential , anterior cingulate cortex , precuneus , dementia , cholinergic , neuroscience , posterior cingulate , cardiology , endocrinology , psychology , cortex (anatomy) , pathology , disease , receptor , cognition
elderly) of the McGill University Research Centre for Studies in Aging (MCSA) were used for this analysis. Patients in the MCSA study have been diagnosed with AD or MCI, by a panel of neurologists based on their cognitive evaluation and the presence of both amyloid and tau neuropathology. Multi-echo T2* data were collected from all participants and iron (R2*) was quantitatively assessed by amono-exponential fit on a voxel-wise basis. Neuroimaging analyses were performed using the VoxelStats toolbox, a MATLAB-based analytical framework that allows for the execution of voxel-wise multimodal neuroimaging analyses. Results: Iron load and age showed a positive correlation in the caudate and putamen (Figure 1). Furthermore, in our cohort, AD patients showed increased iron levels in the prefrontal cortex (Figure 2). Results were corrected for multiple comparisons using an FDR threshold of 0.05 and cluster threshold of 0.001. Conclusions: The positive associations of iron load with age and AD diagnosis support a role for iron in AD pathophysiology. Whereas healthy aging is characterized by subcortical iron accumulation, AD patients demonstrate iron deposition in the cortex. Whether iron is a primary or rather a secondary factor of AD pathoetiology remains to be elucidated.