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P2‐376: 18F‐PI2620 TAU‐PET IN PROGRESSIVE SUPRANUCLEAR PALSY: A MULTI‐CENTER EVALUATION
Author(s) -
Brendel Matthias,
Barthel Henryk,
Eimeren Thilo,
Marek Ken,
Beyer Leonie,
Song Mengmeng,
Palleis Carla,
Respondek Gesine,
Sauerbeck Julia,
Hammes Jochen,
Barbe Michael,
Onur Oezguer A.,
Jessen Frank,
Saur Dorothee,
Schroeter Matthias L.,
Rumpf Jost-Julian,
Rullmann Michael,
Schildan Andreas,
Patt Marianne,
Barret Oliver,
Madonia Jennifer,
Russell David,
Stephens Andrew Wills,
Roeber Sigrun,
Herms Jochen,
Boetzel Kai,
Levin Johannes,
Classen Joseph,
Höglinger Günter,
Bartenstein Peter,
Drzezga Alexander,
Seibyl John,
Sabri Osama
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2783
Subject(s) - progressive supranuclear palsy , tauopathy , globus pallidus , medicine , nuclear medicine , atrophy , pathology , disease , basal ganglia , neurodegeneration , central nervous system
model(s) assessed using the Akaike criterion. Volumes of distribution (VT) and tracer delivery (K1) are estimated using both 1T2k_VB and 2T4k_VB models. Data are analyzed using a simplified reference tissue model (SRTM) with centrum semiovale as the reference region, providing estimates of BPND. We are also examining the effect of the plasma input model and scan duration on model preferences, parameter estimation and TRT. Results: [C] UCB-J shows rapid kinetics and had highest radioactivity concentrations in the grey matter regions and lowest in the white matter region centrum semiovale. Both 1T2k_VB and 2T4k_VB described the kinetics equally well. VT obtained from both models were similar, suggesting that a 1T2k_VB model is sufficient to assess the in vivo kinetics. Shortening the scan duration to 60 min has a negligible effect on VT and BPND. Preliminary analysis shows that the mean absolute TRT for VT and BPND was 8.1 6 5.0% and 7.86 11.5% in 7 healthy subjects across brain regions, respectively.Conclusions: [C]UCB-J kinetics are characterized well by a plasma input single tissue compartment model. Reliable fits can be obtained with a 60 min scan duration for both plasma input and reference tissue models. Preliminary analysis shows mean absolute TRT for VT and BPND of <10% across brain regions and supports the use [C]UCB-J in longitudinal clinical studies.