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P2‐374: CORRELATION OF QUANTITATIVE SUSCEPTIBILITY MAPPING AND COGNITIVE DYSFUNCTION IN MIXED ALZHEIMER'S AND VASCULAR DEMENTIA
Author(s) -
Lee Hyunwoo,
Wiggermann Vanessa,
Rauscher Alexander,
Kames Christian,
Beg Mirza Faisal,
Jacova Claudia,
Sossi Vesna,
Benavente Oscar R.,
Pettersen Jacqueline,
Robin Hsiung Ging-Yuek
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2781
Subject(s) - quantitative susceptibility mapping , basal ganglia , putamen , dementia , white matter , montreal cognitive assessment , magnetic resonance imaging , grey matter , pathology , vascular dementia , voxel , medicine , psychology , nuclear medicine , radiology , disease , central nervous system
main effects were observed with regard to overall thalamic asymmetry, the three groups displayed significantly different extents of asymmetry in the ventrolateral thalamic subnucleus (F(2, 701⁄45.28, p1⁄4.007). Specifically, AD displayed greater ventrolateral asymmetry compared to HC (p1⁄4.009) andMCI (p1⁄4.040) favouring left-dominant atrophy (Fig. 2 and Fig. 3). In cognitively impaired participants (MCI and AD), but not HC, greater asymmetry of the ventrolateral subnucleus was associated with poorer RAVLT scores (p1⁄4.034), higher NPI scores (p1⁄4.046), and higher CDR (p1⁄4.007) (Fig. 4). Conclusions: Asymmetry of the ventrolateral thalamus, a subregion involved in short term memory, was associated with greater disease severity in AD and poorer clinical outcomes. These findings suggest the clinically relevant involvement of the thalamus in the pathophysiology of cognitive decline in AD.