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P2‐355: EPIDEMIC SPREADING OF TAU THROUGH HUMAN FUNCTIONAL BRAIN CONNECTIONS
Author(s) -
Vogel Jacob W.,
Medina Yasser Iturria,
Strandberg Olof,
Smith Ruben,
Evans Alan C.,
Hansson Oskar
Publication year - 2019
Publication title -
alzheimer's and dementia
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 6.713
H-Index - 118
eISSN - 1552-5279
pISSN - 1552-5260
DOI - 10.1016/j.jalz.2019.06.2762
Subject(s) - entorhinal cortex , human connectome project , resting state fmri , neuroscience , connectome , dementia , tau pathology , psychology , alzheimer's disease , hippocampal formation , medicine , functional connectivity , pathology , disease
measures show an association with BA35, where less awareness (lower score) is associated with thinner BA35 (Figures 1-2). For the longitudinal analyses, both anosagnosia measures are associated with a more widespread MTL atrophy pattern. Conclusions: In prodromal AD consistent, though weak, cross-sectional associations were found between anosagnosia measures and BA35, an early site of neurofibrillary tangles (NFT) pathology. Anosagnosia was associated with a more widespread pattern of MTL atrophy longitudinally, likely reflecting progression of NFT pathology. This indicates that selective atrophy in BA35 and adjacent regions may contribute to awareness deficits in prodromal AD, potentially by interfering with updating of self-knowledge as proposed by the Cognitive Awareness Model (Morris and Mograbi, Cortex 2013).